Direct correlation between cholesterol synthesis and hepatic secretion of apolipoprotein B-100 in normolipidemic subjects.

@article{Watts1995DirectCB,
  title={Direct correlation between cholesterol synthesis and hepatic secretion of apolipoprotein B-100 in normolipidemic subjects.},
  author={Gerald F. M. Watts and R. Naoumova and Michele Cummings and A. Margot Umpleby and B. M. Slavin and P. H. S{\"o}nksen and Gilbert R. Thompson},
  journal={Metabolism: clinical and experimental},
  year={1995},
  volume={44 8},
  pages={
          1052-7
        }
}
The regulation of apolipoprotein B-100 (apo B) metabolism in man is not fully understood. In vitro studies suggest a key role for the hepatic availability of cholesterol substrate. We therefore examined whether there was a direct association between plasma mevalonic acid (MVA) concentration (an index of in vivo cholesterol synthesis) and hepatic secretion of very-low-density lipoprotein (VLDL) apo B in eight normolipidemic, healthy adult subjects. Hepatic secretion of VLDL apo B was estimated… CONTINUE READING
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