Direct conversion of porcine embryonic fibroblasts into adipocytes by chemical molecules.

@article{Zhu2012DirectCO,
  title={Direct conversion of porcine embryonic fibroblasts into adipocytes by chemical molecules.},
  author={Jianguo G. Zhu and Daxin Pang and Yang Zhou and Xiaochun Tang and Yongye Huang and Wanhua Xie and Fei Gao and Liangxue Lai and Mingjun Zhang and Hongsheng Ouyang},
  journal={Cellular reprogramming},
  year={2012},
  volume={14 2},
  pages={99-105}
}
Direct reprogramming of terminally differentiated cells to specify different cell types may allow somatic cells to be reprogrammed to an alternative, differentiated fate without intervening stem or progenitor cells. Recent studies have shown that the conversion of fibroblasts to other cell lines can be accomplished by the introduction of master regulator transcription factors. These findings have raised the question as to whether chemical molecules could replace transcription factor cocktails… CONTINUE READING