Direct conversion of human fibroblasts to multilineage blood progenitors

  title={Direct conversion of human fibroblasts to multilineage blood progenitors},
  author={E L Szabo and Shravanti Rampalli and Ruth M. Risue{\~n}o and Angelique Schnerch and Ryan R. Mitchell and Aline A. Fiebig-Comyn and Marilyne Levadoux-Martin and Mickie Bhatia},
As is the case for embryo-derived stem cells, application of reprogrammed human induced pluripotent stem cells is limited by our understanding of lineage specification. Here we demonstrate the ability to generate progenitors and mature cells of the haematopoietic fate directly from human dermal fibroblasts without establishing pluripotency. Ectopic expression of OCT4 (also called POU5F1)-activated haematopoietic transcription factors, together with specific cytokine treatment, allowed… 

Reprogramming Human Endothelial to Hematopoietic Cells Requires Vascular Induction

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Haematopoietic stem and progenitor cells from human pluripotent stem cells

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The major aim of this review is to summarize historical perspectives and recent advances in the investigation of endothelial to hematopoietic transition (EHT) and HSC formation in the context of aiding in vitro approaches to instruct HSC fate from human pluripotent stem cells.

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Direct conversion of mouse fibroblasts into induced neural stem cells

A protocol to directly convert mouse fibroblasts into self-renewing induced neural stem cells (iNSCs) that can be expanded in vitro, thereby overcoming the limitations associated with low reprogramming efficiency.

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Lost in translation: pluripotent stem cell-derived hematopoiesis

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Induced Pluripotent Stem Cell Lines Derived from Human Somatic Cells

Somatic cell nuclear transfer allows trans-acting factors present in the mammalian oocyte to reprogram somatic cell nuclei to an undifferentiated state. We show that four factors (OCT4, SOX2, NANOG,

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Direct reprogramming of human neural stem cells by OCT4

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