Direct conversion of human fibroblasts to multilineage blood progenitors

@article{Szabo2010DirectCO,
  title={Direct conversion of human fibroblasts to multilineage blood progenitors},
  author={E L Szabo and Shravanti Rampalli and Ruth M. Risue{\~n}o and Angelique Schnerch and Ryan R. Mitchell and Aline A. Fiebig-Comyn and Marilyne Levadoux-Martin and Mickie Bhatia},
  journal={Nature},
  year={2010},
  volume={468},
  pages={521-526}
}
As is the case for embryo-derived stem cells, application of reprogrammed human induced pluripotent stem cells is limited by our understanding of lineage specification. Here we demonstrate the ability to generate progenitors and mature cells of the haematopoietic fate directly from human dermal fibroblasts without establishing pluripotency. Ectopic expression of OCT4 (also called POU5F1)-activated haematopoietic transcription factors, together with specific cytokine treatment, allowed… 

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