Direct conversion of human fibroblasts into retinal pigment epithelium-like cells by defined factors

@inproceedings{Zhang2013DirectCO,
  title={Direct conversion of human fibroblasts into retinal pigment epithelium-like cells by defined factors},
  author={Kejing Zhang and Guang-Hui Liu and Fei Yi and Nuria Montserrat and Tomoaki Hishida and Concepci{\'o}n Rodr{\'i}guez Esteban and Juan Carlos Izpisua Belmonte},
  booktitle={Protein & Cell},
  year={2013}
}
The generation of functional retinal pigment epithelium (RPE) is of great therapeutic interest to the field of regenerative medicine and may provide possible cures for retinal degenerative diseases, including age-related macular degeneration (AMD). Although RPE cells can be produced from either embryonic stem cells or induced pluripotent stem cells, direct cell reprogramming driven by lineage-determining transcription factors provides an immediate route to their generation. By monitoring a… CONTINUE READING
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