Direct conversion of glucose to malate by synthetic metabolic engineering.

  title={Direct conversion of glucose to malate by synthetic metabolic engineering.},
  author={Xiaoting Ye and Kohsuke Honda and Yumi Morimoto and Kenji Okano and Hisao Ohtake},
  journal={Journal of biotechnology},
  volume={164 1},
Synthetic metabolic engineering enables us to construct an in vitro artificial synthetic pathways specialized for chemical manufacturing through the simple heat-treatment of the recombinant mesophiles having thermophilic enzymes, followed by rational combination of those biocatalytic modules. In this work, we constructed a synthetic pathway capable of direct conversion of glucose to malate. The reversible carboxylation of pyruvate catalyzed by a malic enzyme derived from Thermococcus… CONTINUE READING

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