Direct control of the Forkhead transcription factor AFX by protein kinase B

@article{Kops1999DirectCO,
  title={Direct control of the Forkhead transcription factor AFX by protein kinase B},
  author={Geert J.P.L. Kops and Nancy D. de Ruiter and Alida M.M. de Vries-Smits and David Rodney Powell and Johannes L Bos and Boudewijn M. Th. Burgering},
  journal={Nature},
  year={1999},
  volume={398},
  pages={630-634}
}
The phosphatidylinositol-3-OH-kinase (PI(3)K) effector protein kinase B (refs 1, 2) regulates certain insulin-responsive genes,, but the transcription factors regulated by protein kinase B have yet to be identified. Genetic analysis in Caenorhabditis elegans has shown that the Forkhead transcription factor daf -16 is regulated by a pathway consisting of insulin-receptor-like daf- 2 and PI(3)K-like age -1 (refs 5–8). Here we show that protein kinase B phosphorylates AFX, a human orthologue of… CONTINUE READING
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