Direct contractile effect of endothelin-1 on isolated circular smooth muscle cells of guinea pig caecum.

@article{Okabe1995DirectCE,
  title={Direct contractile effect of endothelin-1 on isolated circular smooth muscle cells of guinea pig caecum.},
  author={Hiroaki Okabe and Yoshiharu Chijiiwa and Mariko Yoshinaga and Tadashi Misawa and Teppei Kabemura and Hajime Nawata},
  journal={Digestion},
  year={1995},
  volume={56 1},
  pages={21-4}
}
Smooth muscle cells isolated from the circular muscle layers of the guinea pig caecum were used to determine whether endothelin-1 (ET-1) can cause contraction by exerting a direct action on smooth muscle cells. In addition, the inhibitory effects of 8-(N,N-diethylamino)-octyl-3,4,5-trimethoxybenzoate hydrochloride (TMB-8), an inhibitor of intracellular Ca2+ release, verapamil, a Ca2+ channel blocker, and removal of extracellular Ca2+ on the ET-1-induced muscle contraction were examined. ET-1… CONTINUE READING