Direct competition between Brinker and Drosophila Mad in Dpp target gene transcription.

  title={Direct competition between Brinker and Drosophila Mad in Dpp target gene transcription.},
  author={Elisabeth Saller and Mariann Bienz},
  journal={EMBO reports},
  volume={2 4},
Brinker is a nuclear protein that antagonizes Dpp signalling in Drosophila. Its expression is negatively regulated by Dpp. Here, we show that Brinker represses Ultrabithorax (Ubx) in the embryonic midgut, a HOX gene that activates, and responds to, the localized expression of Dpp during endoderm induction. We find that the functional target for Brinker repression coincides with the Dpp response sequence in the Ubx midgut enhancer, namely a tandem of binding sites for the Dpp effector Mad. We… CONTINUE READING
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