Direct comparison of umbilical cord blood versus bone marrow-derived endothelial precursor cells in mediating neovascularization in response to vascular ischemia.

@article{Finney2006DirectCO,
  title={Direct comparison of umbilical cord blood versus bone marrow-derived endothelial precursor cells in mediating neovascularization in response to vascular ischemia.},
  author={Marcie R. Finney and Nicholas J. Greco and S E. A - DePuy AcroMed Haynesworth and Joseph M. Martin and David P. Hedrick and Jimmy Z. Swan and Daniel G. Winter and Suzanne Kadereit and Matthew E. Joseph and Pingfu Fu and Vincent J. Pompili and Mary J. Laughlin},
  journal={Biology of blood and marrow transplantation : journal of the American Society for Blood and Marrow Transplantation},
  year={2006},
  volume={12 5},
  pages={585-93}
}
Endothelial precursor cells (EPCs) cultured from adult bone marrow (BM) have been shown to mediate neovasculogenesis in murine models of vascular injury. We sought to directly compare umbilical cord blood (UCB)- and BM-derived EPC surface phenotypes and in vivo functional capacity. UCB and BM EPCs derived from mononuclear cells (MNC) were phenotyped by surface staining for expression of stromal (Stro-1, CXCR4, CD105, and CD73), endothelial (CD31, CD146, and vascular endothelial [VE]-cadherin… CONTINUE READING