Direct comparison of two different mesalamine formulations for the induction of remission in patients with ulcerative colitis: A double-blind, randomized study

@inproceedings{Ito2010DirectCO,
  title={Direct comparison of two different mesalamine formulations for the induction of remission in patients with ulcerative colitis: A double-blind, randomized study},
  author={Hiroaki Ito and Mitsuo Iida and Takayuki Matsumoto and Yasuo Suzuki and Hidetaka Sasaki and Toyomitsu Yoshida and Yuichi Takano and Toshifumi Hibi},
  booktitle={Inflammatory bowel diseases},
  year={2010}
}
BACKGROUND Mesalamine is the first-line drug for the treatment of ulcerative colitis (UC). We directly compared the efficacy and safety of two mesalamine formulations for the induction of remission in patients with UC. METHODS In a multicenter, double-blind, randomized study, 229 patients with mild-to-moderate active UC were assigned to 4 groups: 66 and 65 received a pH-dependent release formulation of 2.4 g/day (pH-2.4 g) or 3.6 g/day (pH-3.6 g), respectively; 65 received a time-dependent… CONTINUE READING

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