Direct chemical evidence for sphingolipid domains in the plasma membranes of fibroblasts.

Abstract

Sphingolipids play important roles in plasma membrane structure and cell signaling. However, their lateral distribution in the plasma membrane is poorly understood. Here we quantitatively analyzed the sphingolipid organization on the entire dorsal surface of intact cells by mapping the distribution of (15)N-enriched ions from metabolically labeled (15)N… (More)
DOI: 10.1073/pnas.1216585110

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