Direct characterization of drug glucuronide isomers in human urine by HPLC-NMR spectroscopy: application to the positional isomers of 6,11-dihydro-11-oxodibenz[b,e]oxepin-2-acetic acid glucuronide.

@article{Lenz1996DirectCO,
  title={Direct characterization of drug glucuronide isomers in human urine by HPLC-NMR spectroscopy: application to the positional isomers of 6,11-dihydro-11-oxodibenz[b,e]oxepin-2-acetic acid glucuronide.},
  author={Eva Maria Lenz and D Greatbanks and Ian D Wilson and Manfred Spraul and Martin Hofmann and Jeff Troke and John C. Lindon and Jeremy K. Nicholson},
  journal={Analytical chemistry},
  year={1996},
  volume={68 17},
  pages={2832-7}
}
In this work, 400 and 600 MHz 1H HPLC-NMR spectroscopic methods were developed and applied to separate and identify the positional glucuronide isomers and anomers of the model nonsteroidal antiinflammatory drug, 6,11-dihydro-11-oxodibenz[b,e]oxepin-2-acetic acid, in whole human urine. The HPLC methods utilized either an isocratic system, comprising 30… CONTINUE READING