Direct cellular communications between CD45R0 and CD45RA T cell subsets via CD27/CD70.

@article{Agematsu1995DirectCC,
  title={Direct cellular communications between CD45R0 and CD45RA T cell subsets via CD27/CD70.},
  author={Kazunaga Agematsu and Tetsuji Kobata and Kenji Sugita and Tomonori Hirose and Stuart F. Schlossman and Chikao Morimoto},
  journal={Journal of immunology},
  year={1995},
  volume={154 8},
  pages={3627-35}
}
The engagement of CD27 with its ligand CD70 is considered to play an important role in T cell costimulation. In the present study, we investigated both the kinetics of CD70 expression and the contribution of its interaction with CD27 in T cell immune responses. CD70 was found to be expressed almost equally on both activated CD4 and CD8 T cells. On subsets of CD4 T cells, however, CD70 expression was induced preferentially on the CD45R0 T cell population after activation, whereas its expression… CONTINUE READING

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