Direct cell reprogramming is a stochastic process amenable to acceleration

@article{Hanna2009DirectCR,
  title={Direct cell reprogramming is a stochastic process amenable to acceleration},
  author={J. Hanna and K. Saha and B. Pando and J. V. van Zon and C. Lengner and M. Creyghton and A. van Oudenaarden and R. Jaenisch},
  journal={Nature},
  year={2009},
  volume={462},
  pages={595 - 601}
}
  • J. Hanna, K. Saha, +5 authors R. Jaenisch
  • Published 2009
  • Biology, Medicine
  • Nature
  • Direct reprogramming of somatic cells into induced pluripotent stem (iPS) cells can be achieved by overexpression of Oct4, Sox2, Klf4 and c-Myc transcription factors, but only a minority of donor somatic cells can be reprogrammed to pluripotency. Here we demonstrate that reprogramming by these transcription factors is a continuous stochastic process where almost all mouse donor cells eventually give rise to iPS cells on continued growth and transcription factor expression. Additional inhibition… CONTINUE READING
    944 Citations
    Continuous passages accelerate the reprogramming of mouse induced pluripotent stem cells.
    • 7
    Dissecting and Modeling a Transcriptional Dynamics During Stochastic Phase of Somatic Reprogramming
    • Highly Influenced
    Novel Regulators of Somatic Cell Reprogramming
    • Highly Influenced
    • PDF
    Induced pluripotent stem cells: opportunities and challenges
    • K. Okita, S. Yamanaka
    • Biology, Medicine
    • Philosophical Transactions of the Royal Society B: Biological Sciences
    • 2011
    • 221
    • PDF
    Direct reprogramming of mouse fibroblasts to neural progenitors
    • J. Kim, J. Efe, +6 authors S. Ding
    • Biology, Medicine
    • Proceedings of the National Academy of Sciences
    • 2011
    • 510
    • PDF
    DNA Synthesis Is Required for Reprogramming Mediated by Stem Cell Fusion
    • 65
    Butyrate Promotes Induced Pluripotent Stem Cell Generation*
    • 123
    • PDF

    References

    SHOWING 1-10 OF 62 REFERENCES
    Linking the p53 tumor suppressor pathway to somatic cell reprogramming
    • 638
    • PDF
    Senescence impairs successful reprogramming to pluripotent stem cells.
    • 535
    • PDF
    In vitro reprogramming of fibroblasts into a pluripotent ES-cell-like state
    • 1,919
    • PDF
    Reprogramming of somatic cell identity.
    • 35
    • PDF