Direct cardiac effects in isolated perfused rat hearts of fentanyl and remifentanil.

@article{Grkan2005DirectCE,
  title={Direct cardiac effects in isolated perfused rat hearts of fentanyl and remifentanil.},
  author={Aydin G{\"u}rkan and Yelken Birg{\"u}l and Kaygusuz Ziya},
  journal={Annals of cardiac anaesthesia},
  year={2005},
  volume={8 2},
  pages={140-4}
}
Opioids are widely used as analgesics to supplement general anaesthesia or as adjunct to anaesthetic agents and for long term analgesia and sedation in intensive care patients. Some clinical studies have suggested that opioids may have different and deleterious haemodynamic effects that remain incompletely examined. We compared the direct cardiac effects of fentanyl and remifentanil in isolated Wistar rat hearts. Twenty rats were randomly assigned to two groups. Hearts were perfused with… CONTINUE READING