Direct cadherin-activated cell signaling

  title={Direct cadherin-activated cell signaling},
  author={Alpha S. Yap and E. M. Kovacs},
  journal={The Journal of Cell Biology},
  pages={11 - 16}
Classical cadherin adhesion molecules are key determinants of cell recognition and tissue morphogenesis, with diverse effects on cell behavior. Recent developments indicate that classical cadherins are adhesion-activated signaling receptors. In particular, early-immediate Rac signaling is emerging as a mechanism to coordinate cadherin-actin integration at the plasma membrane. 

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