Direct binding of CDC20 protein family members activates the anaphase-promoting complex in mitosis and G1.

@article{Fang1998DirectBO,
  title={Direct binding of CDC20 protein family members activates the anaphase-promoting complex in mitosis and G1.},
  author={Guowei Fang and Hongtao Yu and Marc W Kirschner},
  journal={Molecular cell},
  year={1998},
  volume={2 2},
  pages={163-71}
}
Activation of the anaphase-promoting complex (APC) is required for anaphase initiation and for exit from mitosis. We show that APC is activated during mitosis and G1 by two regulatory factors, hCDC20 and hCDH1. These proteins directly bind to APC and activate its cyclin ubiquitination activity. hCDC20 confers a strict destruction-box (D-box) dependence on APC, while hCDH1 shows a much more relaxed specificity for the D-box. In HeLa cells, the protein levels of hCDC20 as well as its binding to… CONTINUE READING
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