Direct arylation of pyridines without the use of a transition metal catalyst.


A method for achieving the direct arylation of pyridines with phenylhydrazine hydrochloride was developed in this study. This new reaction proceeds readily at room temperature without the use of any transition metal catalysts. This method allows rapid access to various arylated heterocycles that are more difficult to access through traditional methods. 
DOI: 10.1039/c4cc02546f

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