Direct antioxidant and protective effect of estradiol on isolated mitochondria.

  title={Direct antioxidant and protective effect of estradiol on isolated mitochondria.},
  author={Consuelo Borr{\'a}s and Juan Pablo Gambini and Ra{\'u}l L{\'o}pez-Grueso and Federico Vicente Pallard{\'o} and J. Vi{\~n}a},
  journal={Biochimica et biophysica acta},
  volume={1802 1},
Estrogens have antioxidant properties which are due to their ability to bind to estrogen receptors and to up-regulate the expression of antioxidant enzymes via intracellular signalling pathways. Mitochondria are key organelles in the development of age-associated cellular damage. Recently, estrogen receptors were identified in mitochondria. The aim of this paper was to test whether estradiol directly affects mitochondria by preventing oxidative stress and protecting frail mitochondria… CONTINUE READING
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