Direct and specific chemical control of eukaryotic translation with a synthetic RNA–protein interaction

@inproceedings{Goldfless2012DirectAS,
  title={Direct and specific chemical control of eukaryotic translation with a synthetic RNA–protein interaction},
  author={Stephen J. Goldfless and Brian J. Belmont and Alexandra M. de Paz and Jessica F. Liu and Jacquin C Niles},
  booktitle={Nucleic acids research},
  year={2012}
}
Sequence-specific RNA-protein interactions, though commonly used in biological systems to regulate translation, are challenging to selectively modulate. Here, we demonstrate the use of a chemically-inducible RNA-protein interaction to regulate eukaryotic translation. By genetically encoding Tet Repressor protein (TetR)-binding RNA elements into the 5'-untranslated region (5'-UTR) of an mRNA, translation of a downstream coding sequence is directly controlled by TetR and tetracycline analogs. In… CONTINUE READING
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