Direct and mediated effects of testosterone: The development of intersexes in sex reversed mosaic mice, heterozygous for testicular feminization

@article{Drews2004DirectAM,
  title={Direct and mediated effects of testosterone: The development of intersexes in sex reversed mosaic mice, heterozygous for testicular feminization},
  author={U. Drews},
  journal={Anatomy and Embryology},
  year={2004},
  volume={146},
  pages={325-340}
}
  • U. Drews
  • Published 2004
  • Biology, Medicine
  • Anatomy and Embryology
SummaryThe X-linked Tfm mutation causes androgen insensitivity in the target cells of testosterone. Due to random X-inactivation, XX-mice heterozygous for Tfm are mosaics in respect to androgen sensitivity. By the autosomal “sex reversal” mutation, Tfm-heterozygotes were converted to males during embryonic life so that male sex organs developed in which the mosaic was expressed. The mutual influence of both components of the mosaic is analysed. It is shown that cellular differentiation is… Expand
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