Direct and macrophage-mediated actions of fatty acids causing insulin resistance in muscle cells.

@article{Bilan2009DirectAM,
  title={Direct and macrophage-mediated actions of fatty acids causing insulin resistance in muscle cells.},
  author={Phillip J Bilan and Victor Samokhvalov and Alexandra Koshkina and Jonathan D Schertzer and M Constantine Samaan and Amira Klip},
  journal={Archives of physiology and biochemistry},
  year={2009},
  volume={115 4},
  pages={
          176-90
        }
}
Obesity is associated with insulin resistance and increased risk for developing type 2 diabetes. Enlarged adipocytes develop resistance to the anti-lipolytic action of insulin. Elevated levels of fatty acids in the plasma and interstitial fluids lead to whole-body insulin resistance by disrupting normal insulin-regulated glucose uptake and glycogen storage in skeletal muscle. A new understanding has been cultivated in the past 5 to 10 years that adipocytes and macrophages (resident or bone… CONTINUE READING

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