Direct and indirect targeting of MYC to treat acute myeloid leukemia

@inproceedings{Brondfield2015DirectAI,
  title={Direct and indirect targeting of MYC to treat acute myeloid leukemia},
  author={Sam Brondfield and Sushma Umesh and Alexandra Corella and Johannes Zuber and Amy R. Rappaport and Coline Gaillard and Scott W Lowe and Andrei Goga and Scott Kogan},
  booktitle={Cancer Chemotherapy and Pharmacology},
  year={2015}
}
Acute myeloid leukemia (AML) is the most common acute leukemia in adults and is often resistant to conventional therapies. The MYC oncogene is commonly overexpressed in AML but has remained an elusive target. We aimed to examine the consequences of targeting MYC both directly and indirectly in AML overexpressing MYC/Myc due to trisomy 8/15 (human/mouse), FLT3-ITD mutation, or gene amplification. We performed in vivo knockdown of Myc (shRNAs) and both in vitro and in vivo experiments using four… CONTINUE READING
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