Direct and indirect responses to metabotropic glutamate receptor activation in the brain.

@article{Kendall1993DirectAI,
  title={Direct and indirect responses to metabotropic glutamate receptor activation in the brain.},
  author={D. Kendall},
  journal={Biochemical Society transactions},
  year={1993},
  volume={21 4},
  pages={
          1120-3
        }
}
  • D. Kendall
  • Published 1993
  • Biology, Medicine
  • Biochemical Society transactions
Introduction Glutamate is the most important excitatory transmitter substance in the central nervous system and, as is generally the case for information-carrying biomolecules, extends its range by having multiple recognition sites coupled to different post-receptor signalling systems. The receptors for glutamate can be divided broadly into ionotropics, which are coupled to ion channels and mediate fast (ms time-scale) responses (N-methyl-l)-aspartate, a-amino-3-hydroxyl-Sniethylisoxazole-4… Expand
Metabotropic glutamate receptor agonist increases neuropeptide mRNA expression in rat striatum.
Metabotropic glutamate receptors (mGluR) are coupled to multiple intracellular second messenger systems through G-proteins and densely expressed by medium spiny projection neurons in the ratExpand
Interactions between ionotropic and metabotropic glutamate receptors regulate cAMP response element-binding protein phosphorylation in cultured striatal neurons
TLDR
Results indicate a facilitatory regulation of an NMDA cascade to CREB phosphorylation by concurrent glutamatergic tone on mGluR5, which is probably processed via an intracellular signaling pathway involving protein kinase C. Expand
Glutamate cascade to cAMP response element-binding protein phosphorylation in cultured striatal neurons through calcium-coupled group I metabotropic glutamate receptors.
TLDR
It is found that selective activation of group I mGluRs was able to up-regulate CREB phosphorylation in neurochemically identified gamma-aminobutyratergic neurons but not glia. Expand
Sustained Behavioral Stimulation Following Selective Activation of Group I Metabotropic Glutamate Receptors in Rat Striatum
TLDR
Data indicate that selective activation of the DHPG-sensitive group I mGluRs in the striatum can produce long-lasting stimulation of motor activity, independent of D(1) dopaminergic transmission. Expand
Group I metabotropic glutamate receptor‐mediated calcium signalling and immediate early gene expression in cultured rat striatal neurons
TLDR
The results demonstrate that group I mGluRs are able to affect Ca2+ homeostasis at multiple levels and trigger Ca2-‐sensitive gene transcription in striatal neurons. Expand
Regulation of immediate early gene c-fos and zif/268 mRNA expression in rat striatum by metabotropic glutamate receptor.
  • J. Wang
  • Biology, Medicine
  • Brain research. Molecular brain research
  • 1998
TLDR
A difference is demonstrated between the profound induction of c-fos and zif/268 gene expression in response to specific activation of metabotropic glutamate receptors in striatal neurons in chronically-cannulated rats. Expand
Selective activation of group I metabotropic glutamate receptors upregulates preprodynorphin, substance P, and preproenkephalin mRNA expression in rat dorsal striatum
TLDR
Data obtained demonstrate a facilitatory, dynamic regulation of constitutive expression of PPD, SP, and PPE mRNAs by local enhancement of glutamatergic tone on DHPG‐ and PHCCC‐sensitive Group I mGluRs. Expand
Distinct inhibition of acute cocaine-stimulated motor activity following microinjection of a group III metabotropic glutamate receptor agonist into the dorsal striatum of rats
TLDR
The data indicate that the glutamatergic tone on the group III mGluRs is not active in the regulation of basal and acute dopamine-stimulated motor activity, but enhanced group IIImGluR glutamaters transmission by an exogenous ligand is capable of suppressing behavioral responses to acute exposure of dopamine stimulants. Expand
Activation of metabotropic glutamate receptor mediates upregulation of transcription factor mRNA expression in rat striatum induced by acute administration of amphetamine
TLDR
Data indicate that blockade of total mGluRs in the dorsal striatum has a selective effect on dopamine-stimulated gene expression, which is required for the upregulation of transcription factor c-fos, although not zif/268, mRNA expression in the striatum in response to acute injection of amphetamine. Expand
Phosphorylation of cAMP response element‐binding protein in cultured striatal neurons by metabotropic glutamate receptor subtype 5
TLDR
A positive linkage from surface mGluR5 to CREB phosphorylation is demonstrated, which is able to facilitate immediate gene expression in striatal neurons. Expand
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