Direct and indirect mechanisms for regulation of fatty acid synthase gene expression by liver X receptors.

@article{Joseph2002DirectAI,
  title={Direct and indirect mechanisms for regulation of fatty acid synthase gene expression by liver X receptors.},
  author={Sean B. Joseph and Bryan A. Laffitte and Parthive H. Patel and Michael A. Watson and Karen E Matsukuma and Robert Walczak and Jon L. Collins and Timothy F. Osborne and Peter Tontonoz},
  journal={The Journal of biological chemistry},
  year={2002},
  volume={277 13},
  pages={11019-25}
}
The nuclear receptors LXRalpha and LXRbeta have been implicated in the control of lipogenesis and cholesterol homeostasis. Ligand activation of these receptors in vivo induces expression of the LXR target gene SREBP-1c and increases plasma triglyceride levels. Expression of fatty acid synthase (FAS), a central enzyme in de novo lipogenesis and an… CONTINUE READING