Direct and indirect interactions in the recognition between a cross‐neutralizing antibody and the four serotypes of dengue virus

  title={Direct and indirect interactions in the recognition between a cross‐neutralizing antibody and the four serotypes of dengue virus},
  author={Olesia Lisova and Laurent Belkadi and Hugues Bedouelle},
  journal={Journal of Molecular Recognition},
Dengue fever is the most important vector‐borne viral disease. Four serotypes of dengue virus, DENV1 to DENV4, coexist. Secondary infection by a different serotype is a risk factor for severe dengue. Monoclonal antibody mAb4E11 neutralizes the four serotypes of DENV with varying efficacies by recognizing an epitope located within domain‐III (ED3) of the viral envelope (E) protein. To better understand the cross‐reactivities between mAb4E11 and the four serotypes of DENV, we constructed… 

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