Direct and indirect induction by 1,25-dihydroxyvitamin D3 of the NOD2/CARD15-defensin beta2 innate immune pathway defective in Crohn disease.

@article{Wang2010DirectAI,
  title={Direct and indirect induction by 1,25-dihydroxyvitamin D3 of the NOD2/CARD15-defensin beta2 innate immune pathway defective in Crohn disease.},
  author={Tian-tian Wang and Basel Dabbas and David Laperri{\`e}re and Ari J Bitton and Hafid Soualhine and Luz Elisa Tavera-Mendoza and Serge Dionne and Marc J. Servant and Alain Bitton and Ernest G Seidman and Sylvie Mader and Marcel A. Behr and John H. White},
  journal={The Journal of biological chemistry},
  year={2010},
  volume={285 4},
  pages={2227-31}
}
Vitamin D signaling through its nuclear vitamin D receptor has emerged as a key regulator of innate immunity in humans. Here we show that hormonal vitamin D, 1,25-dihydroxyvitamin D(3), robustly stimulates expression of pattern recognition receptor NOD2/CARD15/IBD1 gene and protein in primary human monocytic and epithelial cells. The vitamin D receptor signals through distal enhancers in the NOD2 gene, whose function was validated by chromatin immunoprecipitation and chromatin conformation… CONTINUE READING
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2005)Mol. Endocrinol

  • T. T. Wang, L. E. Tavera-Mendoza, +9 authors J. H. White
  • J. Biol. Chem. 10.1074/jbc.C109.071225
  • 2010

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