Direct and indirect effects of parathyroid hormone on circulating levels of fibroblast growth factor 23 in vivo.

@article{Lopez2011DirectAI,
  title={Direct and indirect effects of parathyroid hormone on circulating levels of fibroblast growth factor 23 in vivo.},
  author={Ignacio Lopez and Marien Encarnacion Rodriguez-Ortiz and Yolanda Almad{\'e}n and F{\'a}tima Guerrero and Addy Montes de Oca and Carmen Pineda and Vicky Shalhoub and Mariano Rodr{\'i}guez and Escolastico Aguilera-Tejero},
  journal={Kidney international},
  year={2011},
  volume={80 5},
  pages={475-82}
}
Fibroblastic growth factor 23 (FGF23) is a bone-derived hormone that has a pivotal role in the pathogenesis of mineral disorders in chronic kidney disease. To study the effect of parathyroid hormone (PTH) on FGF23, rats were parathyroidectomized for a week and then implanted with constant-delivery infusion pumps to provide vehicle, a physiological, or a threefold supraphysiological dose of parathyroid hormone. Parathyroidectomy resulted in a significant decrease in blood ionized calcium, FGF23… CONTINUE READING
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