Direct and indirect effects of growth hormone receptor ablation on liver expression of xenobiotic metabolizing genes.

Abstract

Detoxification of ingested xenobiotic chemicals, and of potentially toxic endogenous metabolites, is carried out largely through a series of enzymes synthesized in the liver, sometimes called "xenobiotic metabolizing enzymes" (XME). Expression of these XME is sexually dimorphic in rodents and humans, with many of the XME expressed at higher levels in… (More)
DOI: 10.1152/ajpendo.00304.2013

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