Direct and indirect contributions of RNA secondary structure elements to the initiation of HIV-1 reverse transcription.

@article{Goldschmidt2002DirectAI,
  title={Direct and indirect contributions of RNA secondary structure elements to the initiation of HIV-1 reverse transcription.},
  author={Val{\'e}rie Goldschmidt and Mickael Rigourd and Chantal Ehresmann and Stuart F. J. Le Grice and Bernard Ehresmann and Roland Marquet},
  journal={The Journal of biological chemistry},
  year={2002},
  volume={277 45},
  pages={43233-42}
}
Initiation of human immunodeficiency virus type 1 (HIV-1) reverse transcription requires specific recognition between the viral RNA (vRNA), tRNA(3)(Lys), which acts as primer, and reverse transcriptase (RT). The specificity of this ternary complex is mediated by intricate interactions between the HIV-1 RNA and tRNA(3)(Lys). Here, we compared the relative importance of the secondary structure elements of this complex in the initiation process. To this aim, we used the previously published three… CONTINUE READING

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