Direct and indirect challenges in the clinical assessment of asthma.

@article{Cockcroft2009DirectAI,
  title={Direct and indirect challenges in the clinical assessment of asthma.},
  author={Donald W. Cockcroft and Beth E. Davis},
  journal={Annals of allergy, asthma & immunology : official publication of the American College of Allergy, Asthma, & Immunology},
  year={2009},
  volume={103 5},
  pages={363-9; quiz 369-72, 400}
}
OBJECTIVE To compare direct and indirect bronchoprovocation challenges in the clinical assessment of asthma. DATA SOURCES PubMed search using the keywords adenosine monophosphate, eucapnic voluntary hyperpnea, exercise, hypertonic saline, mannitol, and methacholine challenges and asthma. STUDY SELECTION Articles were selected based on their relevance to the topic of this review. RESULTS Methacholine is the most widely used direct challenge. Methacholine is highly sensitive, provided… CONTINUE READING