Direct and indirect antioxidant properties of inducers of cytoprotective proteins.

  title={Direct and indirect antioxidant properties of inducers of cytoprotective proteins.},
  author={Albena T Dinkova-Kostova and Paul Talalay},
  journal={Molecular nutrition & food research},
  volume={52 Suppl 1},
Cellular protection against oxidative and electrophile toxicities is provided by two types of small-molecule antioxidants: (i) direct antioxidants, which are redox active, short-lived, are sacrificed in the process of their antioxidant actions and need to be replenished or regenerated, and may evoke pro-oxidant effects; and (ii) indirect antioxidants, that may or may not be redox active. Indirect antioxidants activate the Keap1/Nrf2/ARE pathway resulting in transcriptional induction of a… CONTINUE READING


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