Direct and fast determination of antiretroviral drugs by automated online solid-phase extraction-liquid chromatography-tandem mass spectrometry in human plasma.

@article{Koal2006DirectAF,
  title={Direct and fast determination of antiretroviral drugs by automated online solid-phase extraction-liquid chromatography-tandem mass spectrometry in human plasma.},
  author={Therese Koal and Martin Sibum and Emile Koster and Klaus Resch and Volkhard Kaever},
  journal={Clinical chemistry and laboratory medicine},
  year={2006},
  volume={44 3},
  pages={299-305}
}
BACKGROUND In this study antiretroviral drugs of the classes protease inhibitors (PI) and non-nucleoside reverse transcriptase inhibitors (NNRTI) were quantified for the first time directly in patient plasma samples by means of an automated and validated online solid-phase extraction-liquid chromatography-tandem mass spectrometry (XLC-MS/MS) method using… CONTINUE READING