Direct and distant antitumor effects of a telomerase-selective oncolytic adenoviral agent, OBP-301, in a mouse prostate cancer model

@article{Huang2008DirectAD,
  title={Direct and distant antitumor effects of a telomerase-selective oncolytic adenoviral agent, OBP-301, in a mouse prostate cancer model},
  author={P Huang and Masami Watanabe and Hiroaki Kaku and Yuji Kashiwakura and Jin-Shing Chen and Takashi Saika and Yasutomo Nasu and Tomohiro Fujiwara and Yasuo Urata and Hiromi Kumon},
  journal={Cancer Gene Therapy},
  year={2008},
  volume={15},
  pages={315-322}
}
We previously constructed OBP-301 (Telomelysin, a telomerase-specific replication-competent adenovirus with human telomerase reverse transcriptase (hTERT) promoter), which showed a strong anticancer effect by inducing cell lysis of human non-small cell lung cancer and colorectal cancer cells. To investigate the utility of OBP-301 for prostate cancer treatment, we herein evaluate the cell killing and antitumor effects. First, in vitro hTERT-specific adenovirus transduction in human prostate… CONTINUE READING
22 Citations
17 References
Similar Papers

Citations

Publications citing this paper.
Showing 1-10 of 22 extracted citations

References

Publications referenced by this paper.
Showing 1-10 of 17 references

Histone deacetylase inhibitor FR901228 enhances the antitumor effect of telomerase-specific replication-selective adenoviral agent OBP-301 in human lung cancer cells

  • M Taki
  • Exp Cell Res
  • 2006

In vivo imaging of lymph node metastasis with telomerase-specific replication-selective adenovirus

  • F Uno
  • Nat Med
  • 2006

Similar Papers

Loading similar papers…