Direct and Indirect Induction by 1,25-Dihydroxyvitamin D3 of the NOD2/CARD15-Defensin β2 Innate Immune Pathway Defective in Crohn Disease*

@article{Wang2009DirectAI,
  title={Direct and Indirect Induction by 1,25-Dihydroxyvitamin D3 of the NOD2/CARD15-Defensin β2 Innate Immune Pathway Defective in Crohn Disease*},
  author={Tian-Tian Wang and B. Dabbas and D. Laperri{\`e}re and A. J. Bitton and Hafid Soualhine and Luz E. Tavera-Mendoza and S. Dionne and M. Servant and A. Bitton and E. Seidman and S. Mader and M. Behr and J. White},
  journal={The Journal of Biological Chemistry},
  year={2009},
  volume={285},
  pages={2227 - 2231}
}
  • Tian-Tian Wang, B. Dabbas, +10 authors J. White
  • Published 2009
  • Biology, Medicine
  • The Journal of Biological Chemistry
  • Vitamin D signaling through its nuclear vitamin D receptor has emerged as a key regulator of innate immunity in humans. Here we show that hormonal vitamin D, 1,25-dihydroxyvitamin D3, robustly stimulates expression of pattern recognition receptor NOD2/CARD15/IBD1 gene and protein in primary human monocytic and epithelial cells. The vitamin D receptor signals through distal enhancers in the NOD2 gene, whose function was validated by chromatin immunoprecipitation and chromatin conformation… CONTINUE READING
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