Direct analysis of indomethacin in rat plasma using a column-switching high-performance liquid chromatographic system.

Abstract

We have established a robust, fully automated analytical method for the determination of indomethacin in rat plasma using a column-switching high-performance chromatographic system. The system consists of a precolumn and an analytical column connected in series via a switching valve. When a 50-microl portion of rat plasma containing a therapeutic level of… (More)

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