Direct allosteric regulation between the GAF domain and catalytic domain of photoreceptor phosphodiesterase PDE6.

@article{Zhang2008DirectAR,
  title={Direct allosteric regulation between the GAF domain and catalytic domain of photoreceptor phosphodiesterase PDE6.},
  author={Xiu-Jun Zhang and Karyn B. Cahill and Ary{\'e} Elfenbein and Vadim Y Arshavsky and R. Hertzberger-ren Cote},
  journal={The Journal of biological chemistry},
  year={2008},
  volume={283 44},
  pages={29699-705}
}
Photoreceptor cGMP phosphodiesterase (PDE6) is the central enzyme in the visual transduction cascade. The PDE6 catalytic subunit contains a catalytic domain and regulatory GAF domains. Unlike most GAF domain-containing cyclic nucleotide phosphodiesterases, little is known about direct allosteric communication of PDE6. In this study, we demonstrate for the first time direct, inter-domain allosteric communication between the GAF and catalytic domains in PDE6. The binding affinity of PDE6 for… CONTINUE READING
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