Direct agonist/antagonist functions of dehydroepiandrosterone.

  title={Direct agonist/antagonist functions of dehydroepiandrosterone.},
  author={Fang Chen and Kristin A Knecht and Elizabeth T Birzin and John Berton Fisher and Hilary Wilkinson and Marina Mojena and Consuelo Tudela Moreno and Azriel Schmidt and Shun-ichi Harada and Leonard P. Freedman and Alfred A. Reszka},
  volume={146 11},
Dehydroepiandrosterone (DHEA) exhibits peak adrenal secretion in the fetus at term and around age 30 yr in the adult. Levels then progressively decline, which is associated with decreased levels of testosterone, dihydrotestosterone, and estrogen in peripheral tissues. DHEA supplementation in postmenopausal women increases bone formation and density, an effect mainly attributed to peripheral conversion to sex hormones. In this study, we tested DHEA for direct effects on the androgen (AR) and… CONTINUE READING


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