Direct administration of 2-Hydroxypropyl-Beta-Cyclodextrin into guinea pig cochleae: Effects on physiological and histological measurements

@inproceedings{Lichtenhan2017DirectAO,
  title={Direct administration of 2-Hydroxypropyl-Beta-Cyclodextrin into guinea pig cochleae: Effects on physiological and histological measurements},
  author={Jeffery T. Lichtenhan and Kensuke Hirose and Craig Alan Buchman and Robert Keith Duncan and Alec Salt},
  booktitle={PloS one},
  year={2017}
}
2-Hydroxypropyl-Beta-Cyclodextrin (HPβCD) can be used to treat Niemann-Pick type C disease, Alzheimer's disease, and atherosclerosis. But, a consequence is that HPβCD can cause hearing loss. HPβCD was recently found to be toxic to outer hair cells (OHCs) in the organ of Corti. Previous studies on the chronic effects of in vivo HPβCD toxicity did not know the intra-cochlear concentration of HPβCD and attributed variable effects on OHCs to indirect drug delivery to the cochlea. We studied the… CONTINUE READING

Citations

Publications citing this paper.
Showing 1-3 of 3 extracted citations

Inner ear drug delivery: Recent advances, challenges, and perspective.

European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences • 2019
View 6 Excerpts
Highly Influenced

References

Publications referenced by this paper.
Showing 1-10 of 45 references

Measurement of Ototoxicity Following Intracochlear Bisphosphonate Delivery.

Otology & neurotology : official publication of the American Otological Society, American Neurotology Society [and] European Academy of Otology and Neurotology • 2016

Similar Papers

Loading similar papers…