Direct activation of the ion channel TRPA1 by Ca2+

  title={Direct activation of the ion channel TRPA1 by Ca2+},
  author={Sandra Zurborg and Brian Yurgionas and Julia A. Jira and Ombretta Caspani and Paul A Heppenstall},
  journal={Nature Neuroscience},
TRPA1 is an ion channel expressed by nociceptors and activated by irritant compounds such as mustard oil. The endogenous function of TRPA1 has remained unclear, a fact highlighted by ongoing debate over its potential role as a sensor of noxious cold. Here we show that intracellular Ca2+ activates human TRPA1 via an EF-hand domain and that cold sensitivity… CONTINUE READING