Direct activation of protein phosphatase-2A0 by HIV-1 encoded protein complex NCp7:vpr.

@article{Tung1997DirectAO,
  title={Direct activation of protein phosphatase-2A0 by HIV-1 encoded protein complex NCp7:vpr.},
  author={H Y Tung and Hugues de Rocquigny and Ling Zhao and Xavier Cayla and B. Roques and Ren{\'e} Ozon},
  journal={FEBS letters},
  year={1997},
  volume={401 2-3},
  pages={197-201}
}
The effects of HIV-1 encoded proteins NCp7, vpr and NCp7:vpr complex on the activity of protein phosphatase-2A0 have been tested. We report that NCp7 is an activator of protein phosphatase-2A0 and that vpr activated protein phosphatase-2A0 only slightly. We also report that NCp7 and vpr form a tight complex which becomes a more potent activator of protein phosphatase-2A0 than NCp7 alone. The ability of NCp7 to activate protein phosphatase-2A0 is regulated by vpr. The C-terminal portion of vpr… CONTINUE READING