Direct activation of mitochondrial K(ATP) channels mimics preconditioning but protein kinase C activation is less effective in middle-aged rat hearts.

@article{Tani2001DirectAO,
  title={Direct activation of mitochondrial K(ATP) channels mimics preconditioning but protein kinase C activation is less effective in middle-aged rat hearts.},
  author={Mariho Tani and Yukako Honma and Haruhiko Hasegawa and Kayoko Tamaki},
  journal={Cardiovascular research},
  year={2001},
  volume={49 1},
  pages={
          56-68
        }
}
OBJECTIVES This study is aimed to determine whether loss of preconditioning (IP) effects in the middle-aged hearts (MA) is due to the failure of protein kinase C (PKC) activation and, if so, whether direct activation of mitochondrial ATP-sensitive potassium channels (m-K(ATP)) or PKC mimics IP. BACKGROUND PKC is a mediator and m-K(ATP) may be its downstream effector of IP in young adult hearts (YA), but we have demonstrated that IP is not effective in MA. METHODS AND RESULTS Isolated hearts… CONTINUE READING

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