Direct activation of human phospholipase C by its well known inhibitor u73122.

@article{Klein2011DirectAO,
  title={Direct activation of human phospholipase C by its well known inhibitor u73122.},
  author={Ryan R. Klein and David Bourdon and Chester Lee Costales and Craig D. Wagner and Wendy L White and J. Dudley Williams and Stephanie N. Hicks and John E Sondek and Dhiren R. Thakker},
  journal={The Journal of biological chemistry},
  year={2011},
  volume={286 14},
  pages={12407-16}
}
Phospholipase C (PLC) enzymes are an important family of regulatory proteins involved in numerous cellular functions, primarily through hydrolysis of the polar head group from inositol-containing membrane phospholipids. U73122 (1-(6-((17β-3-methoxyestra-1,3,5(10)-trien-17-yl)amino)hexyl)-1H-pyrrole-2,5-dione), one of only a few small molecules reported to inhibit the activity of these enzymes, has been broadly applied as a pharmacological tool to implicate PLCs in diverse experimental… CONTINUE READING

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