Direct activation of cloned K(atp) channels by intracellular acidosis.

Abstract

ATP-sensitive K(+) (K(ATP)) channels may be regulated by protons in addition to ATP, phospholipids, and other nucleotides. Such regulation allows a control of cellular excitability in conditions when pH is low but ATP concentration is normal. However, whether the K(ATP) changes its activity with pH alterations remains uncertain. In this study we showed that… (More)

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@article{Xu2001DirectAO, title={Direct activation of cloned K(atp) channels by intracellular acidosis.}, author={H. Xu and Ning Cui and Z. Yang and Joseph Wu and Lola Giwa and Lujain Younis Abdulkadir and P. Sharma and C. Jiang}, journal={The Journal of biological chemistry}, year={2001}, volume={276 16}, pages={12898-902} }