Direct activation of K(Ca) channel in airway smooth muscle by nitric oxide: involvement of a nitrothiosylation mechanism?

@article{Abderrahmane1998DirectAO,
  title={Direct activation of K(Ca) channel in airway smooth muscle by nitric oxide: involvement of a nitrothiosylation mechanism?},
  author={Alioua Abderrahmane and Dany Salvail and Marc Dumoulin and Jack Garon and A Cadieux and Eric Rousseau},
  journal={American journal of respiratory cell and molecular biology},
  year={1998},
  volume={19 3},
  pages={
          485-97
        }
}
Clinically, nitric oxide (NO*) is widely used as a pulmonary vaso- and bronchodilator agent. However, the precise molecular mechanisms by which NO. induces smooth muscle relaxation are not well established. It has been suggested that NO. relaxes airway smooth muscle (ASM) via a 3',5'-cyclic guanosine monophosphate (cGMP)-dependent pathway, and our previous work has shown that Ca2+-activated K+ (KCa) channels are susceptible to cGMP-dependent protein kinase (PKG)-dependent phosphorylation (A… CONTINUE READING

Citations

Publications citing this paper.
SHOWING 1-10 OF 40 CITATIONS

Nitric oxide inhibits ADP-ribosyl cyclase through a cGMP-independent pathway in airway smooth muscle.

  • American journal of physiology. Lung cellular and molecular physiology
  • 2002
VIEW 4 EXCERPTS
CITES BACKGROUND
HIGHLY INFLUENCED

Epoxyeicosatrienoic acids relax airway smooth muscles and directly activate reconstituted KCa channels.

  • American journal of physiology. Lung cellular and molecular physiology
  • 1998
VIEW 5 EXCERPTS
CITES RESULTS, BACKGROUND & METHODS

Physiology of nitric oxide in the respiratory system.

  • Physiological research
  • 2017
VIEW 2 EXCERPTS
CITES BACKGROUND

Nitric oxide as a target for the hypotensive and vasorelaxing effects induced by (Z)-ethyl 12-nitrooxy-octadec-9-enoate in rats.

  • European journal of pharmaceutical sciences : official journal of the European Federation for Pharmaceutical Sciences
  • 2014
VIEW 2 EXCERPTS
CITES BACKGROUND

References

Publications referenced by this paper.
SHOWING 1-10 OF 50 REFERENCES

Redox modulation of hslo Ca2+-activated K+ channels.

  • The Journal of neuroscience : the official journal of the Society for Neuroscience
  • 1997
VIEW 5 EXCERPTS
HIGHLY INFLUENTIAL