Corpus ID: 32505173

Direct action of interferon and inducers of interferon on tumor cells in athymic nude mice.

@article{Rivire1983DirectAO,
  title={Direct action of interferon and inducers of interferon on tumor cells in athymic nude mice.},
  author={Y. Rivi{\'e}re and A. Hovanessian},
  journal={Cancer research},
  year={1983},
  volume={43 10},
  pages={
          4596-9
        }
}
  • Y. Riviére, A. Hovanessian
  • Published 1983
  • Biology, Medicine
  • Cancer research
  • Two interferon-mediated enzyme activities, the protein kinase and pppA (2'p5'A)n synthetase (2-5A synthetase) were used to assess the presence and action of interferon on HeLa tumor cells in athymic nude mice. The protein kinase is manifested by the phosphorylation of endogenous proteins with a molecular weight of 67,000 and 72,000 in mouse and human cells, respectively. Treatment of HeLa tumor-bearing mice with mouse interferon (alpha and beta) resulted in enhanced levels of 2-5A synthetase… CONTINUE READING
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