Direct Visualization of HIV-1 Replication Intermediates Shows that Capsid and CPSF6 Modulate HIV-1 Intra-nuclear Invasion and Integration.

Abstract

Direct visualization of HIV-1 replication would improve our understanding of the viral life cycle. We adapted established technology and reagents to develop an imaging approach, ViewHIV, which allows evaluation of early HIV-1 replication intermediates, from reverse transcription to integration. These methods permit the simultaneous evaluation of both the… (More)
DOI: 10.1016/j.celrep.2015.10.036

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@article{Chin2015DirectVO, title={Direct Visualization of HIV-1 Replication Intermediates Shows that Capsid and CPSF6 Modulate HIV-1 Intra-nuclear Invasion and Integration.}, author={Christopher R. Chin and Jill M Perreira and George Savidis and Jocelyn M Portmann and Aaron M Aker and Eric M. Feeley and Miles C. Smith and Abraham L. Brass}, journal={Cell reports}, year={2015}, volume={13 8}, pages={1717-31} }