Direct Visualization of Antigen-specific CD8+T Cells during the Primary Immune Response to Epstein-Barr Virus In Vivo

@article{Callan1998DirectVO,
  title={Direct Visualization of Antigen-specific CD8+T Cells during the Primary Immune Response to Epstein-Barr Virus In Vivo },
  author={M Callan and Linda Tan and Nicola E. Annels and G Ogg and J W Wilson and C. A. O'Callaghan and Neil M. Steven and A. J. McMichael and A. B. Rickinson},
  journal={The Journal of Experimental Medicine},
  year={1998},
  volume={187},
  pages={1395 - 1402}
}
Primary infection with virus can stimulate a vigorous cytotoxic T cell response. The magnitude of the antigen-specific component versus the bystander component of a primary T cell response remains controversial. In this study, we have used tetrameric major histocompatibility complex-peptide complexes to directly visualize antigen-specific cluster of differentration (CD)8+ T cells during the primary immune response to Epstein-Barr virus (EBV) infection in humans. We show that massive expansion… CONTINUE READING
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