Direct Synthesis of Amides from Alcohols and Amines with Liberation of H2

@article{Gunanathan2007DirectSO,
  title={Direct Synthesis of Amides from Alcohols and Amines with Liberation of H2},
  author={Chidambaram Gunanathan and Yehoshoa Ben‐David and David Milstein},
  journal={Science},
  year={2007},
  volume={317},
  pages={790 - 792}
}
Given the widespread importance of amides in biochemical and chemical systems, an efficient synthesis that avoids wasteful use of stoichiometric coupling reagents or corrosive acidic and basic media is highly desirable. We report a reaction in which primary amines are directly acylated by equimolar amounts of alcohols to produce amides and molecular hydrogen (the only products) in high yields and high turnover numbers. This reaction is catalyzed by a ruthenium complex based on a dearomatized… Expand
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