Direct Retino-Raphe Projection Alters Serotonergic Tone and Affective Behavior

@inproceedings{Ren2013DirectRP,
  title={Direct Retino-Raphe Projection Alters Serotonergic Tone and Affective Behavior},
  author={Chaoran Ren and Liju Luan and Benson Wui-Man Lau and Xin Huang and Jian Yang and Yuan Zhou and Xihong Wu and Jie Gao and Gary E. Pickard and Kwok-fai So and Mingliang Pu},
  booktitle={Neuropsychopharmacology},
  year={2013}
}
Light is a powerful modulator of higher-order cognitive processes such as mood but it remains unclear which neural circuits mediate the impact of light on affective behavior. We found that light deprivation produces a depressive-like behavioral state that is reversed by activation of direct retinal signals to the serotonergic dorsal raphe nucleus (DRN) in a manner equivalent to treatment with the selective serotonin reuptake inhibitor fluoxetine. Surprisingly, the DRN-projecting retinal… CONTINUE READING